Treg cells: a potential regulator for IL-22 expression?

S Lin, X Yang, D Liang… - International Journal of …, 2014 - pmc.ncbi.nlm.nih.gov
S Lin, X Yang, D Liang, SG Zheng
International Journal of Clinical and Experimental Pathology, 2014pmc.ncbi.nlm.nih.gov
Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate
lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23
and several transcription factors, including STAT3, RORγt, and the AhR are important
stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In
the review, we discuss the updated advancement on Tregs function and its regulatory role
on IL-22 expression.
Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In the review, we discuss the updated advancement on Tregs function and its regulatory role on IL-22 expression.
pmc.ncbi.nlm.nih.gov