[HTML][HTML] Environmental exposures—the missing link in immune responses after transplantation
W Julliard, LA Owens, CA O'Driscoll, JH Fechner… - American Journal of …, 2016 - Elsevier
In transplantation, immunosuppression has been directed at controlling acute responses,
but treatment of chronic rejection has been ineffective. It is possible that factors that have
previously been unaccounted for, such as exposure to inhaled pollution, ultraviolet light, or
loss of the normal equilibrium between the gut immune system and the outside environment
may be responsible for shifting immune responses to an effector/inflammatory phenotype,
which leads to loss of self-tolerance and graft acceptance, and a shift towards autoimmunity …
but treatment of chronic rejection has been ineffective. It is possible that factors that have
previously been unaccounted for, such as exposure to inhaled pollution, ultraviolet light, or
loss of the normal equilibrium between the gut immune system and the outside environment
may be responsible for shifting immune responses to an effector/inflammatory phenotype,
which leads to loss of self-tolerance and graft acceptance, and a shift towards autoimmunity …
