The role of the IL-22/IL-22R1 axis in cancer
Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and
tissue regeneration through pleiotropic effects including pro-survival signaling, cell
migration, dysplasia and angiogenesis. While these functions can prevent initial
establishment of tumors, they can also be hijacked by aggressive cancers to enhance tumor
growth and metastasis. Thus, the role of the IL-22/IL-22R1 axis in cancer is complex and …
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and
tissue regeneration through pleiotropic effects including pro-survival signaling, cell
migration, dysplasia and angiogenesis. While these functions can prevent initial
establishment of tumors, they can also be hijacked by aggressive cancers to enhance tumor
growth and metastasis. Thus, the role of the IL-22/IL-22R1 axis in cancer is complex and …