Skin cancer in organ transplant recipients: more than the immune system
L Wheless, S Jacks, KAM Potter, BC Leach… - Journal of the American …, 2014 - Elsevier
Organ transplant recipients (OTRs) are at increased risk of developing nonmelanoma skin
cancers. This has long been thought to be caused by immunosuppression and viral
infection. However, skin cancer risk among individuals with AIDS or iatrogenic
immunodeficiency does not approach the levels seen in OTRs, suggesting other factors play
a critical role in oncogenesis. In clinical trials of OTRs, switching from calcineurin inhibitors
to mammalian target of rapamycin inhibitors consistently led to a significant reduction in the …
cancers. This has long been thought to be caused by immunosuppression and viral
infection. However, skin cancer risk among individuals with AIDS or iatrogenic
immunodeficiency does not approach the levels seen in OTRs, suggesting other factors play
a critical role in oncogenesis. In clinical trials of OTRs, switching from calcineurin inhibitors
to mammalian target of rapamycin inhibitors consistently led to a significant reduction in the …