[HTML][HTML] The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2) …
J Hayakawa, C Depatie, M Ohmichi… - Journal of Biological …, 2003 - ASBMB
The activating transcription factor 2 (ATF2) is a member of the ATF/cAMP-response element-
binding protein family of basic-leucine zipper proteins involved in cellular stress response.
The transcription potential of ATF2 is enhanced markedly by NH 2-terminal phosphorylation
by c-Jun NH 2-terminal kinase (JNK) and mediates stress responses including DNA-
damaging events. We have observed that four DNA-damaging agents (cisplatin, actinomycin
D, MMS, and etoposide), but not the cisplatin isomer, transplatin, which does not readily …
binding protein family of basic-leucine zipper proteins involved in cellular stress response.
The transcription potential of ATF2 is enhanced markedly by NH 2-terminal phosphorylation
by c-Jun NH 2-terminal kinase (JNK) and mediates stress responses including DNA-
damaging events. We have observed that four DNA-damaging agents (cisplatin, actinomycin
D, MMS, and etoposide), but not the cisplatin isomer, transplatin, which does not readily …