[HTML][HTML] Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1
C Zihni, C Mitsopoulos, IA Tavares, AJ Ridley… - Journal of Biological …, 2006 - ASBMB
We have reported previously that human prostate-derived sterile 20-like kinase (PSK) 1
alters actin cytoskeletal organization and binds to microtubules, regulating their organization
and stability. We have shown a structurally related protein kinase PSK2, which lacks a
microtubule-binding site, activated c-Jun N-terminal kinase (JNK), and induced apoptotic
morphological changes that include cell contraction, membrane blebbing, and apoptotic
body formation. Apoptotic stimuli increased the catalytic activity of endogenous PSK2 and …
alters actin cytoskeletal organization and binds to microtubules, regulating their organization
and stability. We have shown a structurally related protein kinase PSK2, which lacks a
microtubule-binding site, activated c-Jun N-terminal kinase (JNK), and induced apoptotic
morphological changes that include cell contraction, membrane blebbing, and apoptotic
body formation. Apoptotic stimuli increased the catalytic activity of endogenous PSK2 and …