The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation: duration of JNK activation may determine cell death and proliferation
c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli,
environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates
with other signaling pathways and regulates the diverse cellular events are unclear. We
found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-
regulated kinase 2, to be persistently activated in apoptosis induced by γ radiation, UV-C,
and anti-Fas treatment. Direct correlation was found between JNK activation and apoptosis …
environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates
with other signaling pathways and regulates the diverse cellular events are unclear. We
found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-
regulated kinase 2, to be persistently activated in apoptosis induced by γ radiation, UV-C,
and anti-Fas treatment. Direct correlation was found between JNK activation and apoptosis …
