[HTML][HTML] Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection
Frontiers in immunology, 2012•frontiersin.org
A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability
of naïve CTLs to undergo a program of differentiation and proliferation upon activation
resulting in the acquisition of lineage-specific T cell functions and eventual establishment of
immunological memory. In this review, we examine the molecular factors that shape both the
acquisition and maintenance of lineage-specific effector function in virus-specific CTL during
both the effector and memory phases of immunity.
of naïve CTLs to undergo a program of differentiation and proliferation upon activation
resulting in the acquisition of lineage-specific T cell functions and eventual establishment of
immunological memory. In this review, we examine the molecular factors that shape both the
acquisition and maintenance of lineage-specific effector function in virus-specific CTL during
both the effector and memory phases of immunity.
A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.
Frontiers