Multicenter feasibility study of tumor molecular profiling to inform therapeutic decisions in advanced pediatric solid tumors: the individualized cancer therapy (iCat) …

MH Harris, SG DuBois, JLG Bender, AR Kim… - JAMA …, 2016 - jamanetwork.com
Importance Pediatric cancers represent a unique case with respect to cancer genomics and
precision medicine, as the mutation frequency is low, and targeted therapies are less
available. Consequently, it is unknown whether clinical sequencing can be of benefit.
Objective To assess the feasibility of identifying actionable alterations and making
individualized cancer therapy (iCat) recommendations in pediatric patients with extracranial
solid tumors. Design, Setting, and Participants Clinical sequencing study at 4 academic …