Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
MG Kris, BE Johnson, LD Berry, DJ Kwiatkowski… - Jama, 2014 - jamanetwork.com
Importance Targeting oncogenic drivers (genomic alterations critical to cancer development
and maintenance) has transformed the care of patients with lung adenocarcinomas. The
Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing
adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted
treatments and enroll patients into clinical trials. Objectives To determine the frequency of
oncogenic drivers in patients with lung adenocarcinomas and to use the data to select …
and maintenance) has transformed the care of patients with lung adenocarcinomas. The
Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing
adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted
treatments and enroll patients into clinical trials. Objectives To determine the frequency of
oncogenic drivers in patients with lung adenocarcinomas and to use the data to select …