[PDF][PDF] Extracellular 'communicator RNA'
SA Benner - FEBS letters, 1988 - Citeseer
FEBS letters, 1988•Citeseer
Important metabolic and regulatory roles are occasionally discovered for classes of enzymes
once thought to be interesting only to mechanistic enzymologists. For example, no sooner
had enzymologists 'solved'all of the interesting catalytic problems presented by proteases
than proteases were found to play important roles in genetic regulation. Now, proteases are
known to control the expression of genes, to defend against viruses, and perhaps to control
the induction and growth of tumors [l]. Ribonuclease (RNase) may provide a similar story …
once thought to be interesting only to mechanistic enzymologists. For example, no sooner
had enzymologists 'solved'all of the interesting catalytic problems presented by proteases
than proteases were found to play important roles in genetic regulation. Now, proteases are
known to control the expression of genes, to defend against viruses, and perhaps to control
the induction and growth of tumors [l]. Ribonuclease (RNase) may provide a similar story …
Important metabolic and regulatory roles are occasionally discovered for classes of enzymes once thought to be interesting only to mechanistic enzymologists. For example, no sooner had enzymologists ‘solved’all of the interesting catalytic problems presented by proteases than proteases were found to play important roles in genetic regulation. Now, proteases are known to control the expression of genes, to defend against viruses, and perhaps to control the induction and growth of tumors [l].
Ribonuclease (RNase) may provide a similar story. Today, this diminutive protein (13.5 kDa) from the digestive system of cows is thought to be interesting primarily as a model to study folding, catalysis and evolution in proteins [2]. However, recent discoveries promise to revolutionize this view.
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