[HTML][HTML] Innate lymphoid cell type 3–derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB
M Coorens, A Rao, SK Gräfe, D Unelius… - Journal of Biological …, 2019 - ASBMB
Escherichia coli and Klebsiella pneumoniae are opportunistic pathogens that are commonly
associated with infections at mucosal surfaces, such as the lung or the gut. The host
response against these types of infections includes the release of epithelial-derived
antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron
acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging
molecule enterobactin. Regulation of epithelial antimicrobial responses, including the …
associated with infections at mucosal surfaces, such as the lung or the gut. The host
response against these types of infections includes the release of epithelial-derived
antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron
acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging
molecule enterobactin. Regulation of epithelial antimicrobial responses, including the …