Proteome analysis of rat hepatic stellate cells
DB Kristensen, N Kawada, K Imamura, Y Miyamoto… - Hepatology, 2000 - Elsevier
Proteome analysis was performed on cellular and secreted proteins of normal (quiescent)
and activated rat hepatic stellate cells. The stellate cells were activated either in vitro by
cultivating quiescent stellate cells for 9 days or in vivo by injecting rats with carbon
tetrachloride for 8 weeks. A total of 43 proteins/polypeptides were identified, which altered
their expression levels when the cells were activated in vivo and/orin vitro. Twenty-seven of
them showed similar changesin vivo and in vitro, including up-regulated proteins such as …
and activated rat hepatic stellate cells. The stellate cells were activated either in vitro by
cultivating quiescent stellate cells for 9 days or in vivo by injecting rats with carbon
tetrachloride for 8 weeks. A total of 43 proteins/polypeptides were identified, which altered
their expression levels when the cells were activated in vivo and/orin vitro. Twenty-seven of
them showed similar changesin vivo and in vitro, including up-regulated proteins such as …