[HTML][HTML] A TRPC1 protein-dependent pathway regulates osteoclast formation and function

EC Ong, V Nesin, CL Long, CX Bai, JL Guz… - Journal of Biological …, 2013 - ASBMB
Ca 2+ signaling is essential for bone homeostasis and skeletal development. Here, we show
that the transient receptor potential canonical 1 (TRPC1) channel and the inhibitor of MyoD
family, I-mfa, function antagonistically in the regulation of osteoclastogenesis. I-mfa null mice
have an osteopenic phenotype characterized by increased osteoclast numbers and surface,
which are normalized in mice lacking both Trpc1 and I-mfa. In vitro differentiation of pre-
osteoclasts derived from I-mfa-deficient mice leads to an increased number of mature …