[HTML][HTML] Requirement of the TRPC1 cation channel in the generation of transient Ca2+ oscillations by the calcium-sensing receptor
O Rey, SH Young, R Papazyan, MS Shapiro… - Journal of biological …, 2006 - ASBMB
The calcium-sensing receptor (CaR) is an allosteric protein that responds to extracellular Ca
2+([Ca 2+] o) and aromatic amino acids with the production of different patterns of
oscillations in intracellular Ca 2+ concentration ([Ca 2+] i). An increase in [Ca 2+] o
stimulates phospholipase C-mediated production of inositol 1, 4, 5-trisphosphate and
causes sinusoidal oscillations in [Ca 2+] i. Conversely, aromatic amino acid-induced CaR
activation does not stimulate phospholipase C but engages an unidentified signaling …
2+([Ca 2+] o) and aromatic amino acids with the production of different patterns of
oscillations in intracellular Ca 2+ concentration ([Ca 2+] i). An increase in [Ca 2+] o
stimulates phospholipase C-mediated production of inositol 1, 4, 5-trisphosphate and
causes sinusoidal oscillations in [Ca 2+] i. Conversely, aromatic amino acid-induced CaR
activation does not stimulate phospholipase C but engages an unidentified signaling …