Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis
T Kumasaka, K Seyama, K Mitani… - The American journal …, 2005 - journals.lww.com
Lymphangioleiomyomatosis (LAM) affects exclusively women of reproductive age, involves
the lungs and axial lymphatic system, and is frequently complicated with renal
angiomyolipomas. LAM lesions are generated by the proliferation of LAM cells with
mutations of one of the tuberous sclerosis complex (TSC) genes. Recent studies indicate
that LAM cells can migrate or metastasize to form new lesions in multiple organs, although
they show a morphologically benign appearance. In the previous study, we reported LAM …
the lungs and axial lymphatic system, and is frequently complicated with renal
angiomyolipomas. LAM lesions are generated by the proliferation of LAM cells with
mutations of one of the tuberous sclerosis complex (TSC) genes. Recent studies indicate
that LAM cells can migrate or metastasize to form new lesions in multiple organs, although
they show a morphologically benign appearance. In the previous study, we reported LAM …