Biochemical and mechanical properties of subchondral bone in osteoarthritis
AJ Bailey, JP Mansell, TJ Sims, X Banse - Biorheology, 2004 - content.iospress.com
AJ Bailey, JP Mansell, TJ Sims, X Banse
Biorheology, 2004•content.iospress.comThe subchondral bone has long been known to thicken in osteoarthritis. However, recent
evidence has demonstrated that the turnover of the bone is increased several fold, and
further suggests that the thickening occurs prior to degradation of the articular cartilage,
indicating that it plays a role in the pathogenesis of osteoarthritis. The mechanical and
biochemical properties of the subchondral bone are therefore of particular interest in any
attempt to determine the nature of the factors initiating osteoarthritis.
evidence has demonstrated that the turnover of the bone is increased several fold, and
further suggests that the thickening occurs prior to degradation of the articular cartilage,
indicating that it plays a role in the pathogenesis of osteoarthritis. The mechanical and
biochemical properties of the subchondral bone are therefore of particular interest in any
attempt to determine the nature of the factors initiating osteoarthritis.
Abstract
The subchondral bone has long been known to thicken in osteoarthritis. However, recent evidence has demonstrated that the turnover of the bone is increased several fold, and further suggests that the thickening occurs prior to degradation of the articular cartilage, indicating that it plays a role in the pathogenesis of osteoarthritis. The mechanical and biochemical properties of the subchondral bone are therefore of particular interest in any attempt to determine the nature of the factors initiating osteoarthritis.
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