[HTML][HTML] A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-β-driven SMAD3/4 …
F Verrecchia, C Tacheau, EF Wagner… - Journal of Biological …, 2003 - ASBMB
We have focused our attention on the molecular events underlying the antagonistic activities
of pro-inflammatory cytokines against transforming growth factor-β (TGF-β)/SMAD signaling.
Using jnk1/2-knockout (jnk−/−) and IκB kinase-γ/nemo−/− fibroblasts, we have determined
the specific roles played by the JNK/AP-1 and NF-κB/Rel pathways in this phenomenon. We
demonstrate that, in a cellular context devoid of JNK activity (ie jnk−/− fibroblasts), interleukin-
1 and tumor necrosis factor-α (TNF-α) did not inhibit the formation of SMAD-DNA complexes …
of pro-inflammatory cytokines against transforming growth factor-β (TGF-β)/SMAD signaling.
Using jnk1/2-knockout (jnk−/−) and IκB kinase-γ/nemo−/− fibroblasts, we have determined
the specific roles played by the JNK/AP-1 and NF-κB/Rel pathways in this phenomenon. We
demonstrate that, in a cellular context devoid of JNK activity (ie jnk−/− fibroblasts), interleukin-
1 and tumor necrosis factor-α (TNF-α) did not inhibit the formation of SMAD-DNA complexes …
