Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia
A Piechota-Polańczyk, A Gorąca - Pharmacological Reports, 2012 - Elsevier
Background The potent vasoconstrictor endothelin-1 has been implicated in the
pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor
blockers BQ123 andBQ788 were used to investigate the importance of selective endothelin
receptor blockage in modulating oxidative stress during endotoxemia. Methods The study
was performed on male Wistar rats (n= 6 per group) divided into groups:(1) saline,(2)
lipopolysaccharide (LPS)(15 mg\kg)-saline,(3) BQ123 (0.5 mg\kg)-LPS,(4) BQ123 (1 mg\kg) …
pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor
blockers BQ123 andBQ788 were used to investigate the importance of selective endothelin
receptor blockage in modulating oxidative stress during endotoxemia. Methods The study
was performed on male Wistar rats (n= 6 per group) divided into groups:(1) saline,(2)
lipopolysaccharide (LPS)(15 mg\kg)-saline,(3) BQ123 (0.5 mg\kg)-LPS,(4) BQ123 (1 mg\kg) …