The role of action potential alternans in the initiation of atrial fibrillation in humans: a review and future directions
MR Franz, SM Jamal, SM Narayan - Europace, 2012 - academic.oup.com
MR Franz, SM Jamal, SM Narayan
Europace, 2012•academic.oup.comThis review highlights the role of atrial monophasic action potential duration (APD) in
understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial
fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way
appear mechanistically involved in AF initiation, development, and persistence. The
underlying pathophysiology warrants further investigation.
understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial
fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way
appear mechanistically involved in AF initiation, development, and persistence. The
underlying pathophysiology warrants further investigation.
Abstract
This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.
Oxford University Press