This review concentrates on the characteristics and functionality of endocrine neurons in the
hypothalamo-neurohypophysial system, coexpressing two peptides, vasopressin and
apelin. Vasopressin is synthesized in the soma of magnocellular neurons, then packaged in
granules with its respective receptors. In these neurons, apelin is generated from a larger
precursor proapelin and is detected in vesicles, some of them colocalize with vasopressin,
for others there is a marked segregation of apelin and vasopressin immunoreactivity along …