Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology
NS Grotenboer, ME Ketelaar, GH Koppelman… - Journal of allergy and …, 2013 - Elsevier
Asthma is a complex disease that results from the interaction between genetic predisposition
and environmental factors. Recently, genome-wide association studies have identified a
number of genes that significantly contribute to asthma. Two of these genes, IL33 and IL-1
receptor–like 1 (IL1RL1), act in one signal transduction pathway. IL33 encodes a cytokine
released on damage of cells, whereas IL1RL1 encodes part of the IL-33 receptor complex.
Recent progress made in functional studies in human subjects and mouse models of allergic …
and environmental factors. Recently, genome-wide association studies have identified a
number of genes that significantly contribute to asthma. Two of these genes, IL33 and IL-1
receptor–like 1 (IL1RL1), act in one signal transduction pathway. IL33 encodes a cytokine
released on damage of cells, whereas IL1RL1 encodes part of the IL-33 receptor complex.
Recent progress made in functional studies in human subjects and mouse models of allergic …