Purpose Mutations in the tumor suppressor gene BAP1 occur in approximately 15% of clear
cell renal cell carcinoma cases. Sequencing efforts demonstrated worse outcomes in
patients with BAP1 mutated clear cell renal cell carcinoma. We investigated the
clinicopathological significance and oncologic outcomes of BAP1 loss using a previously
validated immunohistochemical assay. Materials and Methods Immunohistochemistry for
BAP1 was performed on tissue microarray sections from 559 nonmetastatic clear cell renal …