Characterization and impact of TERT promoter region mutations on clinical outcome in renal cell carcinoma
J Casuscelli, MF Becerra, BJ Manley, EC Zabor… - European urology …, 2019 - Elsevier
Background Mutations in the promoter region of the TERT gene have been detected in a
variety of cancers. These mutations can potentially lead to unlimited cell divisions and result
in poor clinical prognosis. Objective To determine the role and relevance of TERT promoter
region mutations in both clear cell (ccRCC) and non–clear cell (nccRCC) renal cell
carcinoma using ultra-deep and whole-genome sequencing methods on primary tumor
samples. Design, setting, and participants DNA from 281 kidney tumors (147 ccRCC and …
variety of cancers. These mutations can potentially lead to unlimited cell divisions and result
in poor clinical prognosis. Objective To determine the role and relevance of TERT promoter
region mutations in both clear cell (ccRCC) and non–clear cell (nccRCC) renal cell
carcinoma using ultra-deep and whole-genome sequencing methods on primary tumor
samples. Design, setting, and participants DNA from 281 kidney tumors (147 ccRCC and …