Prognostic significance of pancreatic metastases from renal cell carcinoma in patients treated with tyrosine kinase inhibitors

P Chrom, R Stec, L Bodnar, C Szczylik - Anticancer research, 2018 - ar.iiarjournals.org
P Chrom, R Stec, L Bodnar, C Szczylik
Anticancer research, 2018ar.iiarjournals.org
Aim: The study aimed to define the true impact of pancreatic metastases (PM) from renal cell
carcinoma on overall survival (OS) in patients treated with first-line tyrosine kinase inhibitors.
Patients and Methods: Overall, 321 consecutive patients were analysed. The influence of
PM on OS was assessed using the Kaplan–Meier estimator and the log-rank test
(unadjusted and adjusted) and two multivariabe Cox proportional hazards regressions
(CPHR). Results: Thirty-four patients (10%) had PM and 287 (90%) had sites of metastasis …
Aim
The study aimed to define the true impact of pancreatic metastases (PM) from renal cell carcinoma on overall survival (OS) in patients treated with first-line tyrosine kinase inhibitors.
Patients and Methods
Overall, 321 consecutive patients were analysed. The influence of PM on OS was assessed using the Kaplan–Meier estimator and the log-rank test (unadjusted and adjusted) and two multivariabe Cox proportional hazards regressions (CPHR).
Results
Thirty-four patients (10%) had PM and 287 (90%) had sites of metastasis other than the pancreas; the median OS was 46.1 and 23.1 months, respectively (unadjusted log-rank p=0.020; adjusted log-rank p=0.544). The PM status was an insignificant factor for OS in both CPHR (hazard ratio(HR)=0.84, p=0.603, and HR=0.66, p=0.098).
Conclusion
The presence of PM was not an independent prognostic factor, but was rather an indicator of an indolent course of the disease.
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