Contribution of residual function to removal of protein-bound solutes in hemodialysis
IO Marquez, S Tambra, FY Luo, Y Li… - Clinical Journal of the …, 2011 - journals.lww.com
Results Dialytic clearances of the protein-bound solutes p-cresol sulfate, indoxyl sulfate, and
hippurate were reduced in proportion to the avidity of binding and averaged 8±2, 10±3, and
44±13% of the dialytic urea clearance. For each bound solute, the residual clearance was
larger in relation to the residual urea clearance. Residual kidney function therefore removed
a larger portion of each of the bound solutes than of urea. Increasing residual function was
associated with lower plasma levels of p-cresol sulfate and hippurate but not indoxyl sulfate …
hippurate were reduced in proportion to the avidity of binding and averaged 8±2, 10±3, and
44±13% of the dialytic urea clearance. For each bound solute, the residual clearance was
larger in relation to the residual urea clearance. Residual kidney function therefore removed
a larger portion of each of the bound solutes than of urea. Increasing residual function was
associated with lower plasma levels of p-cresol sulfate and hippurate but not indoxyl sulfate …
