Microbes in the colon produce compounds, normally excreted by the kidneys, which are
potential uremic toxins. Although p-cresol sulfate and indoxyl sulfate are well studied
examples, few other compounds are known. Here, we compared plasma from hemodialysis
patients with and without colons to identify and further characterize colon-derived uremic
solutes. HPLC confirmed the colonic origin of p-cresol sulfate and indoxyl sulfate, but levels
of hippurate, methylamine, and dimethylamine were not significantly lower in patients …