[HTML][HTML] Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
The primary site of mercury-induced injury is the kidney due to uptake of the reactive Hg 2+-
conjugated organic anions in the proximal tubule. Here, we investigated the in vivo role of
Oat1 (organic anion transporter 1; originally NKT (Lopez-Nieto, CE, You, G., Bush, KT,
Barros, EJ, Beier, DR, and Nigam, SK (1997) J. Biol. Chem. 272, 6471–6478)) in handling of
known nephrotoxic doses of HgCl 2. Oat1 (Slc22a6) is a multispecific organic anion drug
transporter that is expressed on the basolateral aspects of renal proximal tubule cells and …
conjugated organic anions in the proximal tubule. Here, we investigated the in vivo role of
Oat1 (organic anion transporter 1; originally NKT (Lopez-Nieto, CE, You, G., Bush, KT,
Barros, EJ, Beier, DR, and Nigam, SK (1997) J. Biol. Chem. 272, 6471–6478)) in handling of
known nephrotoxic doses of HgCl 2. Oat1 (Slc22a6) is a multispecific organic anion drug
transporter that is expressed on the basolateral aspects of renal proximal tubule cells and …