[HTML][HTML] Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
DH Sweet, DS Miller, JB Pritchard, Y Fujiwara… - Journal of Biological …, 2002 - ASBMB
To begin to develop in vivo model systems for the assessment of the contributions of specific
organic anion transporter (OAT) family members to detoxification, development, and
disease, we carried out a targeted disruption of the murine organic anion transporter 3
(Oat3) gene. SurvivingOat3−/− animals appear healthy, are fertile, and do not exhibit any
gross morphological tissue abnormalities. NoOat3 mRNA expression was detected in
kidney, liver, or choroid plexus (CP) of Oat3−/− mice. A distinct phenotype manifested by a …
organic anion transporter (OAT) family members to detoxification, development, and
disease, we carried out a targeted disruption of the murine organic anion transporter 3
(Oat3) gene. SurvivingOat3−/− animals appear healthy, are fertile, and do not exhibit any
gross morphological tissue abnormalities. NoOat3 mRNA expression was detected in
kidney, liver, or choroid plexus (CP) of Oat3−/− mice. A distinct phenotype manifested by a …