A bench to bedside view of uremic toxins

R Vanholder, U Baurmeister, P Brunet… - Journal of the …, 2008 - journals.lww.com
Reviewing the current picture of uremic toxicity reveals its complexity. Focusing on
cardiovascular damage as a model of uremic effects resulting in substantial morbidity and
mortality, most molecules with potential to affect the function of a variety of cell types within
the vascular system are difficult to remove by dialysis. Examples are the larger middle
molecular weight molecules and protein-bound molecules. Recent clinical studies suggest
that enhancing the removal of these compounds is beneficial for survival. Future therapeutic …