Women with preexisting or gestational diabetes mellitus have an increased risk for
developing preeclampsia. Diabetes and pregnancy are both characterized by very high
prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro) renin
receptor has enzymatic activity. We hypothesized that soluble (pro) renin receptor levels are
elevated in high-risk pregnancies. Third trimester maternal blood samples from complicated
pregnancies (n= 165),(preeclampsia [n= 76], diabetes mellitus [type I diabetes, n= 35; type II …