Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes
VS Sabbisetti, SS Waikar, DJ Antoine… - Journal of the …, 2014 - journals.lww.com
Currently, no blood biomarker that specifically indicates injury to the proximal tubule of the
kidney has been identified. Kidney injury molecule-1 (KIM-1) is highly upregulated in
proximal tubular cells following kidney injury. The ectodomain of KIM-1 is shed into the
lumen, and serves as a urinary biomarker of kidney injury. We report that shed KIM-1 also
serves as a blood biomarker of kidney injury. Sensitive assays to measure plasma and
serum KIM-1 in mice, rats, and humans were developed and validated in the current study …
kidney has been identified. Kidney injury molecule-1 (KIM-1) is highly upregulated in
proximal tubular cells following kidney injury. The ectodomain of KIM-1 is shed into the
lumen, and serves as a urinary biomarker of kidney injury. We report that shed KIM-1 also
serves as a blood biomarker of kidney injury. Sensitive assays to measure plasma and
serum KIM-1 in mice, rats, and humans were developed and validated in the current study …