C5a receptor (CD88) blockade protects against MPO-ANCA GN
H Xiao, DJ Dairaghi, JP Powers, LS Ertl… - Journal of the …, 2014 - journals.lww.com
Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin
deposits is associated with ANCA. The most common ANCA target antigens are
myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the
alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO)
induces a mouse model of ANCA NCGN that closely mimics human disease. Here, we
confirm the importance of C5aR/CD88 in the mediation of anti-MPO–induced NCGN and …
deposits is associated with ANCA. The most common ANCA target antigens are
myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the
alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO)
induces a mouse model of ANCA NCGN that closely mimics human disease. Here, we
confirm the importance of C5aR/CD88 in the mediation of anti-MPO–induced NCGN and …