Evaluation of cisplatin and cyclosporin A in recurrent platinum-resistant ovarian cancer: a phase II study of the gynecologic oncology group
A Manetta, JA Blessing, JA Hurteau - Gynecologic oncology, 1998 - Elsevier
A Manetta, JA Blessing, JA Hurteau
Gynecologic oncology, 1998•ElsevierObjective. The objective of this study was to study the effectiveness of cyclosporin A and
cisplatin in patients with recurrent epithelial ovarian cancer. Methods. Twenty-six patients
with measurable recurrent epithelial ovarian cancer, considered to be resistant to cisplatin,
received cisplatin in combination with cyclosporin A. Patients received 75 mg/m2cisplatin
every 3 weeks and two cyclosporin A injections over 2 h each, 24 h apart, at a dose of 4
mg/kg each. Results. Only a single patient had a complete response, with two experiencing …
cisplatin in patients with recurrent epithelial ovarian cancer. Methods. Twenty-six patients
with measurable recurrent epithelial ovarian cancer, considered to be resistant to cisplatin,
received cisplatin in combination with cyclosporin A. Patients received 75 mg/m2cisplatin
every 3 weeks and two cyclosporin A injections over 2 h each, 24 h apart, at a dose of 4
mg/kg each. Results. Only a single patient had a complete response, with two experiencing …
Objective
The objective of this study was to study the effectiveness of cyclosporin A and cisplatin in patients with recurrent epithelial ovarian cancer.
Methods
Twenty-six patients with measurable recurrent epithelial ovarian cancer, considered to be resistant to cisplatin, received cisplatin in combination with cyclosporin A. Patients received 75 mg/m2cisplatin every 3 weeks and two cyclosporin A injections over 2 h each, 24 h apart, at a dose of 4 mg/kg each.
Results
Only a single patient had a complete response, with two experiencing a partial response to cyclosporin A/cisplatin combination. Hematologic toxicity in this study was modest. No patient developed grade 4 renal toxicity.
Conclusion
These data indicate minimal activity of the combination of cyclosporin A and cisplatin in ovarian cancer patients with recurrent measurable disease previously treated with cisplatin and thought to be resistant to this chemotherapeutic agent.
Elsevier