[HTML][HTML] Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in …
T Huang, Z Xie, J Wang, M Li, N Jing, L Li - Journal of Biological Chemistry, 2011 - ASBMB
The Ca 2+ signaling pathway appears to regulate the processes of the early development
through its antagonism of canonical Wnt/β-catenin signaling pathway. However, the
underlying mechanism is still poorly understood. Here, we show that nuclear factor of
activated T cells (NFAT), a component of Ca 2+ signaling, interacts directly with Dishevelled
(Dvl) in a Ca 2+-dependent manner. A dominant negative form of NFAT rescued the
inhibition of the Wnt/β-catenin pathway triggered by the Ca 2+ signal. NFAT functioned …
through its antagonism of canonical Wnt/β-catenin signaling pathway. However, the
underlying mechanism is still poorly understood. Here, we show that nuclear factor of
activated T cells (NFAT), a component of Ca 2+ signaling, interacts directly with Dishevelled
(Dvl) in a Ca 2+-dependent manner. A dominant negative form of NFAT rescued the
inhibition of the Wnt/β-catenin pathway triggered by the Ca 2+ signal. NFAT functioned …