Identification and isolation of slow-dividing cells in human glioblastoma using carboxy fluorescein succinimidyl ester (CFSE)
LP Deleyrolle, MR Rohaus, JM Fortin… - JoVE (Journal of …, 2012 - jove.com
Tumor heterogeneity represents a fundamental feature supporting tumor robustness and
presents a central obstacle to the development of therapeutic strategies1. To overcome the
issue of tumor heterogeneity, it is essential to develop assays and tools enabling
phenotypic,(epi) genetic and functional identification and characterization of tumor
subpopulations that drive specific disease pathologies and represent clinically relevant
targets. It is now well established that tumors exhibit distinct sub-fractions of cells with …
presents a central obstacle to the development of therapeutic strategies1. To overcome the
issue of tumor heterogeneity, it is essential to develop assays and tools enabling
phenotypic,(epi) genetic and functional identification and characterization of tumor
subpopulations that drive specific disease pathologies and represent clinically relevant
targets. It is now well established that tumors exhibit distinct sub-fractions of cells with …
