Interactions between macrophages and cyst-lining epithelial cells promote kidney cyst growth in Pkd1-deficient mice
Y Yang, M Chen, J Zhou, J Lv, S Song… - Journal of the …, 2018 - journals.lww.com
Background Autosomal-dominant polycystic kidney disease (ADPKD) is the leading
inherited renal disease worldwide. The proproliferative function of macrophages is
associated with late-stage cyst enlargement in mice with PKD; however, the way in which
macrophages act on cyst-lining epithelial cells (CLECs) has not been well elucidated.
Methods We generated a rapid-onset PKD mouse model by inactivating Pkd1 on postnatal
day 10 (P10) and compared cell proliferation and differential gene expression in kidney …
inherited renal disease worldwide. The proproliferative function of macrophages is
associated with late-stage cyst enlargement in mice with PKD; however, the way in which
macrophages act on cyst-lining epithelial cells (CLECs) has not been well elucidated.
Methods We generated a rapid-onset PKD mouse model by inactivating Pkd1 on postnatal
day 10 (P10) and compared cell proliferation and differential gene expression in kidney …