[HTML][HTML] microRNA‑214 suppresses the growth of cervical cancer cells by targeting EZH2

Y Yang, Y Liu, G Li, L Li, P Geng… - Oncology …, 2018 - spandidos-publications.com
Y Yang, Y Liu, G Li, L Li, P Geng, H Song
Oncology Letters, 2018spandidos-publications.com
A number of studies have revealed the significance of microRNAs (miRs) in tumorigenesis.
Cervical cancer (CC) is one of the most malignant cancer types and is associated with a
poor overall survival rate. A previous study demonstrated a critical role of miR‑214 in the
development of multiple cancer types, but its role in CC remains elusive. In the current study,
miR‑214 was observed to be downregulated in CC tissues compared with the adjacent non‑
cancerous tissue. Overexpression of miR‑214 reduced the proliferation of CC cells, whereas …
Abstract
A number of studies have revealed the significance of microRNAs (miRs) in tumorigenesis. Cervical cancer (CC) is one of the most malignant cancer types and is associated with a poor overall survival rate. A previous study demonstrated a critical role of miR‑214 in the development of multiple cancer types, but its role in CC remains elusive. In the current study, miR‑214 was observed to be downregulated in CC tissues compared with the adjacent non‑cancerous tissue. Overexpression of miR‑214 reduced the proliferation of CC cells, whereas inhibiting its expression resulted in enhanced proliferation. Furthermore, Enhancer of zeste homolog 2 (EZH2) was demonstrated to be a direct target of miR‑214 in CC. An MTT assay demonstrated that upregulating miR‑214 expression or knocking down the expression of EZH2 impaired the proliferation of a CC cell line. Low expression of miR‑214 was positively associated with tumor differentiation (P= 0.037) and tumor stage (P= 0.012). Notably, low expression of miR‑214 predicted poor prognosis of patients with CC. Consequently, the results of the current study demonstrated that miR‑214 functions as a tumor suppressor in CC and may be regarded as a potential therapeutic target in CC.
Spandidos Publications