Toll-like receptor 4–induced IL-22 accelerates kidney regeneration
OP Kulkarni, I Hartter, SR Mulay… - Journal of the …, 2014 - journals.lww.com
AKI involves early Toll-like receptor (TLR)–driven immunopathology, and resolution of
inflammation is needed for rapid regeneration of injured tubule cells. Notably, activation of
TLRs also has been implicated in epithelial repair. We hypothesized that TLR signaling
drives tubule regeneration after acute injury through the induction of certain ILs. Systematic
screening in vitro identified IL-22 as a candidate proregeneratory factor in primary tubular
cell recovery, and IL-22 deficiency or IL-22 blockade impaired post-ischemic tubular …
inflammation is needed for rapid regeneration of injured tubule cells. Notably, activation of
TLRs also has been implicated in epithelial repair. We hypothesized that TLR signaling
drives tubule regeneration after acute injury through the induction of certain ILs. Systematic
screening in vitro identified IL-22 as a candidate proregeneratory factor in primary tubular
cell recovery, and IL-22 deficiency or IL-22 blockade impaired post-ischemic tubular …