[HTML][HTML] Vascularized osteomyocutaneous allografts are permissive to tolerance by induction-based immunomodulatory therapy
Vascularized composite allografts (VCAs) are unique among transplanted organs in that
they are composed of multiple tissues with disparate antigenic and immunologic properties.
As the predominant indications for VCAs are non-life-threatening conditions, there is an
immediate need to develop tolerance induction strategies and to elucidate the mechanisms
of VCA rejection and tolerance using VCA-specific animal models. In this study, we explore
the effects of in vitro induced donor antigen-specific CD4− CD8− double negative (DN) Treg …
they are composed of multiple tissues with disparate antigenic and immunologic properties.
As the predominant indications for VCAs are non-life-threatening conditions, there is an
immediate need to develop tolerance induction strategies and to elucidate the mechanisms
of VCA rejection and tolerance using VCA-specific animal models. In this study, we explore
the effects of in vitro induced donor antigen-specific CD4− CD8− double negative (DN) Treg …