[HTML][HTML] CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model
A Page, S Srinivasan, K Singh, M Russell… - American Journal of …, 2012 - Elsevier
In murine models, T-cell costimulation blockade of the CD28: B7 and CD154: CD40
pathways synergistically promotes immune tolerance after transplantation. While CD28
blockade has been successfully translated to the clinic, translation of blockade of the
CD154: CD40 pathway has been less successful, in large part due to thromboembolic
complications associated with anti-CD154 antibodies. Translation of CD40 blockade has
also been slow, in part due to the fact that synergy between CD40 blockade and CD28 …
pathways synergistically promotes immune tolerance after transplantation. While CD28
blockade has been successfully translated to the clinic, translation of blockade of the
CD154: CD40 pathway has been less successful, in large part due to thromboembolic
complications associated with anti-CD154 antibodies. Translation of CD40 blockade has
also been slow, in part due to the fact that synergy between CD40 blockade and CD28 …