Intestinal alkaline phosphatase regulates tight junction protein levels
W Liu, D Hu, H Huo, W Zhang… - Journal of the …, 2016 - journals.lww.com
Background Intestinal alkaline phosphatase (IAP) plays a pivotal role in maintaining gut
health and well-being. Oral supplementation with IAP in mice improves gut barrier function
and prevents luminal proinflammatory factors from gaining access to the circulation. In this
study, we sought to explore the relationship between IAP and tight junction protein (TJP)
expression and function. Study Design The effect of IAP deletion on TJP levels was studied
in mouse embryonic fibroblasts (MEFs) generated from IAP-knockout and wild type mice …
health and well-being. Oral supplementation with IAP in mice improves gut barrier function
and prevents luminal proinflammatory factors from gaining access to the circulation. In this
study, we sought to explore the relationship between IAP and tight junction protein (TJP)
expression and function. Study Design The effect of IAP deletion on TJP levels was studied
in mouse embryonic fibroblasts (MEFs) generated from IAP-knockout and wild type mice …