[HTML][HTML] What do we measure when we measure cell-associated HIV RNA

AO Pasternak, B Berkhout - Retrovirology, 2018 - Springer
AO Pasternak, B Berkhout
Retrovirology, 2018Springer
Abstract Cell-associated (CA) HIV RNA has received much attention in recent years as a
surrogate measure of the efficiency of HIV latency reversion and because it may provide an
estimate of the viral reservoir size. This review provides an update on some recent insights
in the biology and clinical utility of this biomarker. We discuss a number of important
considerations to be taken into account when interpreting CA HIV RNA measurements, as
well as different methods to measure this biomarker.
Abstract
Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of this biomarker. We discuss a number of important considerations to be taken into account when interpreting CA HIV RNA measurements, as well as different methods to measure this biomarker.
Springer