[PDF][PDF] HIV reservoir: finding the right needles in a needlestack
AO Pasternak, B Berkhout - Cell host & microbe, 2016 - cell.com
AO Pasternak, B Berkhout
Cell host & microbe, 2016•cell.comHIV Reservoir: Finding the Right Needles in a Needlestack Page 1 what now constitutes a ‘‘typical’’
flavivirus? The more we delve into virus biodiversity, the more it may be that the genome
structure of the small vertebrate flaviviruses, such as HCV and Zika, will be the exception
rather than the norm. Clearly, genome structures have changed dramatically over the
timescale of flavilike virus evolution, with some arthropod flavi-like viruses possessing
genomes longer than 25 kb (Shi et al., 2015), and the evolution of segmented and multicomponent …
flavivirus? The more we delve into virus biodiversity, the more it may be that the genome
structure of the small vertebrate flaviviruses, such as HCV and Zika, will be the exception
rather than the norm. Clearly, genome structures have changed dramatically over the
timescale of flavilike virus evolution, with some arthropod flavi-like viruses possessing
genomes longer than 25 kb (Shi et al., 2015), and the evolution of segmented and multicomponent …
HIV forms a reservoir that persists despite prolonged therapy and is considered the main barrier to an HIV cure. Baxter et al. (2016) in this issue of Cell Host & Microbe and Boritz et al. (2016) in a recent Cell paper shed new light on HIV persistence in infected individuals.
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