Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by
reduced amounts of the mitochondrial protein frataxin. Frataxin levels in research studies
are typically measured via Western blot analysis from patient fibroblasts, lymphocytes, or
muscle biopsies; none of these is ideal for rapid detection in large scale clinical studies.
Recently, a rapid, noninvasive lateral flow immunoassay was developed to accurately
measure picogram levels of frataxin protein and shown to distinguish lymphoblastoid cells …