[HTML][HTML] NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection
N Dikshit, SD Kale, HJ Khameneh, V Balamuralidhar… - Mucosal …, 2018 - Elsevier
The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB
belonging to international clones (ICs) I and II with limited treatment options are major global
health threats. However, the pathogenesis mechanisms of various AB clonal groups are
understudied. Although inflammation-associated interleukin-1β (IL-1β) levels and IL-1
receptor antagonist polymorphisms were previously implicated in MDR-AB-related …
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB
belonging to international clones (ICs) I and II with limited treatment options are major global
health threats. However, the pathogenesis mechanisms of various AB clonal groups are
understudied. Although inflammation-associated interleukin-1β (IL-1β) levels and IL-1
receptor antagonist polymorphisms were previously implicated in MDR-AB-related …