[HTML][HTML] Hormone-sensitive lipase
FB Kraemer, WJ Shen - Journal of lipid research, 2002 - ASBMB
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of
hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as
well as other lipid and water soluble substrates. HSL activity is regulated post-translationally
by phosphorylation and also by pretranslational mechanisms. The enzyme is highly
expressed in adipose tissue and steroidogenic tissues, with lower amounts expressed in
cardiac and skeletal muscle, macrophages, and islets. Studies of the structure of HSL have …
hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as
well as other lipid and water soluble substrates. HSL activity is regulated post-translationally
by phosphorylation and also by pretranslational mechanisms. The enzyme is highly
expressed in adipose tissue and steroidogenic tissues, with lower amounts expressed in
cardiac and skeletal muscle, macrophages, and islets. Studies of the structure of HSL have …