[HTML][HTML] Renal glucose handling in diabetes and sodium glucose cotransporter 2 inhibition
RR Poudel - Indian journal of endocrinology and metabolism, 2013 - journals.lww.com
The kidneys play a major role in glucose homeostasis through its utilization,
gluconeogenesis, and reabsorption via sodium glucose cotransporters (SGLTs). The
defective renal glucose handling from upregulation of SGLTs, mainly the SGLT2, plays a
fundamental role in the pathogenesis of type 2 diabetes mellitus. Genetic mutations in a
SGLT2 isoform that results in benign renal glycosuria, as well as clinical studies with SGLT2
inhibitors in type 2 diabetes support the potential of this approach. These studies indicate …
gluconeogenesis, and reabsorption via sodium glucose cotransporters (SGLTs). The
defective renal glucose handling from upregulation of SGLTs, mainly the SGLT2, plays a
fundamental role in the pathogenesis of type 2 diabetes mellitus. Genetic mutations in a
SGLT2 isoform that results in benign renal glycosuria, as well as clinical studies with SGLT2
inhibitors in type 2 diabetes support the potential of this approach. These studies indicate …