Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition
S Shi, SP Srivastava, M Kanasaki, J He… - Kidney …, 2015 - kidney-international.org
Integrin β1 and dipeptidyl peptidase (DPP)-4 play roles in endothelial cell biology. Vascular
endothelial growth factor (VEGF)-A inhibits endothelial-to-mesenchymal transition (EndMT)
through VEGF-R2, but through VEGF-R1 promotes EndMT by reducing the bioavailability of
VEGF-A. Here we tested whether DPP-4-integrin β1 interactions have a role in EndMT in the
renal fibrosis of diabetic nephropathy. In streptozotocin-induced fibrotic kidneys in diabetic
CD-1 mice, levels of endothelial DPP-4, integrin β1, and phospho-integrin β1 were all higher …
endothelial growth factor (VEGF)-A inhibits endothelial-to-mesenchymal transition (EndMT)
through VEGF-R2, but through VEGF-R1 promotes EndMT by reducing the bioavailability of
VEGF-A. Here we tested whether DPP-4-integrin β1 interactions have a role in EndMT in the
renal fibrosis of diabetic nephropathy. In streptozotocin-induced fibrotic kidneys in diabetic
CD-1 mice, levels of endothelial DPP-4, integrin β1, and phospho-integrin β1 were all higher …
