Diastolic pulmonary vascular pressure gradient: a predictor of prognosis in “out-of-proportion” pulmonary hypertension
C Gerges, M Gerges, MB Lang, Y Zhang, J Jakowitsch… - Chest, 2013 - Elsevier
Background Left-sided heart disease (LHD) is the most common cause of pulmonary
hypertension (PH). In patients with LHD, elevated left atrial pressure causes a passive
increase in pulmonary vascular pressure by hydrostatic transmission. In some patients, an
active component caused by pulmonary arterial vasoconstriction and/or vascular remodeling
superimposed on left-sided pressure elevation is observed. This “reactive” or “out-of-
proportion” PH, defined as PH due to LHD with a transpulmonary gradient (TPG)> 12 mm …
hypertension (PH). In patients with LHD, elevated left atrial pressure causes a passive
increase in pulmonary vascular pressure by hydrostatic transmission. In some patients, an
active component caused by pulmonary arterial vasoconstriction and/or vascular remodeling
superimposed on left-sided pressure elevation is observed. This “reactive” or “out-of-
proportion” PH, defined as PH due to LHD with a transpulmonary gradient (TPG)> 12 mm …